Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning

Hydroxyl radical (•OH) production in the rat striatum during carbon monoxide (CO) poisoning, which inhibits complex IV, was enhanced synergistically by malonate, a mitochondrial complex II inhibitor, but not N-methyl-4-phenylpyridinium or NaCN, complex I and IV inhibitors, respectively. No such enha...

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Main Authors: Fumi Kuriiwa (Author), Masamune Kobayashi (Author), Hajime Mizukami (Author), Shuichi Hara (Author)
Formato: Livro
Publicado em: Elsevier, 2021-05-01T00:00:00Z.
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