Lactate-Dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1

• Main Authors: Stickeler Elmar (Author), Aumann Konrad (Author), Mattern Dominik (Author), Schulte-Uentrop Luzie (Author), Sienel Wulf (Author), Kassem Ahmad (Author), Kayser Gian (Author), Werner Martin (Author), Passlick Bernward (Author), Hausen Axel (Author)
• Format: Book
• Published: BMC, 2010-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Aims</p> <p>As one of the five Lactate dehydrogenase (LDH) isoenzymes, LDH5 has the highest efficiency to catalyze pyruvate transformation to lactate. LDH5 overexpression in cancer cells induces an upregulated glycolytic metabolism and reduced depende...