Mechanism of Statin-Induced Contractile Dysfunction in Rat Cultured Skeletal Myofibers
Abstract.: An adverse effect of statins, cholesterol-lowering drugs, is contractile dysfunction of skeletal muscles. We investigated the mechanism underlying this effect in cultured myofibers isolated from rats. Fluvastatin (Flv) for 72 h decreased caffeine- and ionomycin-induced contraction of myof...
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Elsevier,
2010-01-01T00:00:00Z.
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