Mechanism of Statin-Induced Contractile Dysfunction in Rat Cultured Skeletal Myofibers

• Main Authors: Syoko Tanaka (Author), Kazuho Sakamoto (Author), Masaya Yamamoto (Author), Anna Mizuno (Author), Tomoyuki Ono (Author), Satoshi Waguri (Author), Junko Kimura (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: An adverse effect of statins, cholesterol-lowering drugs, is contractile dysfunction of skeletal muscles. We investigated the mechanism underlying this effect in cultured myofibers isolated from rats. Fluvastatin (Flv) for 72 h decreased caffeine- and ionomycin-induced contraction of myof...