Evaluating in vivo data for drug metabolism and transport: lessons from Kirchhoff's Laws

• मुख्य लेखकों: Leslie Z. Benet (लेखक), Jasleen K. Sodhi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Mechanistic models of hepatic clearance have been evaluated for more than 50 years, with the first author of this mini-review serving as a co-author of the first paper proposing such a model. However, published quality experimental data are only consistent with the first of these models, designated...