PET-based radiomics visualizes tumor-infiltrating CD8 T cell exhaustion to optimize radiotherapy/immunotherapy combination in mouse models of lung cancer

• Main Authors: Ying Zhang (Author), Hui-Hui Hu (Author), Shi-Hong Zhou (Author), Wu-Yan Xia (Author), Yan Zhang (Author), Jian-Ping Zhang (Author), Xiao-Long Fu (Author), Wen Yu (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination is still unclear. The overall infiltration and exhausted subpopulations...