CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin

• Main Authors: Pierre Cardinal (Author), Caroline André (Author), Carmelo Quarta (Author), Luigi Bellocchio (Author), Samantha Clark (Author), Melissa Elie (Author), Thierry Leste-Lasserre (Author), Marlene Maitre (Author), Delphine Gonzales (Author), Astrid Cannich (Author), Uberto Pagotto (Author), Giovanni Marsicano (Author), Daniela Cota (Author)
• Format: Book
• Published: Elsevier, 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic flexibility allows rapid adaptation to dietary change, however, little is known about the CNS mechanisms regulating this process. Neurons in the hypothalamic ventromedial nucleus (VMN) participate in energy balance and are the target of the metabolically relevant hormone leptin. Cannabinoi...