Single-particle cryo-EM of the ryanodine receptor channel
Ryanodine receptors (RyRs) are tetrameric ligand-gated Ca2+ release channels that are responsible for the increase of cytosolic Ca2+ concentration leading to muscle contraction. Our current understanding of RyR channel gating and regulation is greatly limited due to the lack of a high-resolution str...
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PAGEPress Publications,
2015-01-01T00:00:00Z.
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