Single-particle cryo-EM of the ryanodine receptor channel

• Päätekijät: Mariah R. Baker (Tekijä), Guizhen Fan (Tekijä), Irina I. Serysheva (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: PAGEPress Publications, 2015-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Ryanodine receptors (RyRs) are tetrameric ligand-gated Ca2+ release channels that are responsible for the increase of cytosolic Ca2+ concentration leading to muscle contraction. Our current understanding of RyR channel gating and regulation is greatly limited due to the lack of a high-resolution str...