Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant

• Main Authors: Haruki Hirakawa (Author), Kei Taguchi (Author), Seiya Murakawa (Author), Masaya Asano (Author), Soma Noguchi (Author), Satoshi Kikkawa (Author), Kana Harada (Author), Naoko Adachi (Author), Takehiko Ueyama (Author), Izumi Hide (Author), Shigeru Tanaka (Author), Norio Sakai (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flurbiprofen, a nonsteroidal anti-inflammatory drug, reportedly exhibits chemical chaperone activity. Herein, we investigated the role of flurbiprofen in regulating serotonin transporter (SERT) function via membrane trafficking. We used COS-7 cells transiently expressing wild-type (WT) SERT or a C-t...