Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

• Main Authors: Pornparn Kongpracha (Author), Shushi Nagamori (Author), Pattama Wiriyasermkul (Author), Yoko Tanaka (Author), Kazuko Kaneda (Author), Suguru Okuda (Author), Ryuichi Ohgaki (Author), Yoshikatsu Kanai (Author)
• Format: Book
• Published: Elsevier, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

L-type amino acid transporter 1 (LAT1) is known as a cancer-type amino acid transporter. In cancer cells, LAT1 is responsible for the cellular uptake of many essential amino acids including leucine that activates mechanistic/mammalian target of rapamycin (mTOR), regulating cancer cell growth. In thi...