Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

• المؤلفون الرئيسيون: Pornparn Kongpracha (مؤلف), Shushi Nagamori (مؤلف), Pattama Wiriyasermkul (مؤلف), Yoko Tanaka (مؤلف), Kazuko Kaneda (مؤلف), Suguru Okuda (مؤلف), Ryuichi Ohgaki (مؤلف), Yoshikatsu Kanai (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2017-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

L-type amino acid transporter 1 (LAT1) is known as a cancer-type amino acid transporter. In cancer cells, LAT1 is responsible for the cellular uptake of many essential amino acids including leucine that activates mechanistic/mammalian target of rapamycin (mTOR), regulating cancer cell growth. In thi...