Structural principles of insulin formulation and analog design: A century of innovation

• Main Authors: Mark A. Jarosinski (Author), Balamurugan Dhayalan (Author), Yen-Shan Chen (Author), Deepak Chatterjee (Author), Nicolás Varas (Author), Michael A. Weiss (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations to the frontiers of synthetic peptide chemistry, and in turn, from the advent of recombina...