Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

• मुख्य लेखकों: Jie Wen (लेखक), Lingmao Zhao (लेखक), Zhuohan Li (लेखक), Chao Pi (लेखक), Xianhu Feng (लेखक), Peng Shi (लेखक), Hongru Yang (लेखक), Ligang Chen (लेखक), Xiaodong Wang (लेखक), Furong Liu (लेखक), Yumeng Wei (लेखक), Ling Zhao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Chemotherapy remains the first choice of treatment for colon cancer despite the inevitable adverse effects. Curcumin (CU) possesses antitumor activity but has poor aqueous solubility, low bioavailability, and weak activity. To address this, nine novel monocarbonyl CU analogues were designed, synthes...