Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

• Автори: Jie Wen (Автор), Lingmao Zhao (Автор), Zhuohan Li (Автор), Chao Pi (Автор), Xianhu Feng (Автор), Peng Shi (Автор), Hongru Yang (Автор), Ligang Chen (Автор), Xiaodong Wang (Автор), Furong Liu (Автор), Yumeng Wei (Автор), Ling Zhao (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Chemotherapy remains the first choice of treatment for colon cancer despite the inevitable adverse effects. Curcumin (CU) possesses antitumor activity but has poor aqueous solubility, low bioavailability, and weak activity. To address this, nine novel monocarbonyl CU analogues were designed, synthes...