Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule. Using Tn antigen as the model, a three-component vaccine (MPLA-Tn-KRN7000) containing the TLR4 ligand MPLA and the iNKT cell agonist KRN7000 was...

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Hlavní autoři: Deying Yang (Autor), Xiang Luo (Autor), Qinghai Lian (Autor), Lingqiang Gao (Autor), Chengxin Wang (Autor), Xiaoxiao Qi (Autor), Rong Zhang (Autor), Zhongqiu Liu (Autor), Guochao Liao (Autor)
Médium: Kniha
Vydáno: Elsevier, 2022-12-01T00:00:00Z.
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