Th17 down-regulation is involved in reduced progression of schistosomiasis fibrosis in ICOSL KO mice.

• Main Authors: Bo Wang (Author), Song Liang (Author), Yu Wang (Author), Xing-Quan Zhu (Author), Wei Gong (Author), Hui-Qin Zhang (Author), Ying Li (Author), Chao-Ming Xia (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Granulomatous and fibrosing inflammation in response to parasite eggs is the main pathology that occurs during infection with Schistosoma spp. CD4+ T cells play critical roles in both host immune responses against parasitic infection and immunopathology in schistosomiasis,and coordinate many types o...