Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold

• প্রধান লেখক: Yuan Gao (লেখক), Jilong Duan (লেখক), Xiawen Dang (লেখক), Yinghui Yuan (লেখক), Yu Wang (লেখক), Xingrui He (লেখক), Renren Bai (লেখক), Xiang-Yang Ye (লেখক), Tian Xie (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

β-Elemene is the major active ingredient of TCM anticancer drug elemene extracts. To further improve its antitumor activity and poor solubility, a polar HDACi pharmacophore was incorporated its scaffold. Systematic SAR studies led to the discovery of compounds 27f and 39f, which exhibited potent inh...