A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice

• Main Authors: Masanobu Nagano (Author), Kazuki Kubota (Author), Asuka Sakata (Author), Rei Nakamura (Author), Toru Yoshitomi (Author), Koji Wakui (Author), Keitaro Yoshimoto (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heparin-induced thrombocytopenia (HIT) is a complication caused by administration of the anticoagulant heparin. Although the number of patients with HIT has drastically increased because of coronavirus disease 2019 (COVID-19), the currently used thrombin inhibitors for HIT therapy do not have antido...