Stoichiometry of multi-specific immune checkpoint RNA Abs for T cell activation and tumor inhibition using ultra-stable RNA nanoparticles

• Auteurs principaux: Dan Shu (Auteur), Long Zhang (Auteur), Xuefeng Bai (Auteur), Jianhua Yu (Auteur), Peixuan Guo (Auteur)
• Format: Livre
• Publié: Elsevier, 2021-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Immunotherapy has become a revolutionary subject in cancer therapy during the past few years. Immune checkpoint-targeting antibodies (Abs) could boost anticancer immune responses. However, certain protein-based immunotherapies revealed side effects and unfavorable biodistribution, so effective non-p...