Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages

• Main Authors: Kuo-Feng Hua (Author), Yu-Bei Lin (Author), Hsiao-Wen Chiu (Author), Wei-Ting Wong (Author), Shuk-Man Ka (Author), Chun-Hsien Wu (Author), Wen-Yu Lin (Author), Chien-Chun Wang (Author), Chung-Hua Hsu (Author), Hsien-Ta Hsu (Author), Chen-Lung Ho (Author), Lan-Hui Li (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Worldwide, more than 125 million people are infected with Shigella each year and develop shigellosis. In our previous study, we provided evidence that Shigella sonnei infection triggers activation of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome in macr...