In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

• Main Authors: Marc P Hübner (Author), Marianne Koschel (Author), Dominique Struever (Author), Venelin Nikolov (Author), Stefan J Frohberger (Author), Alexandra Ehrens (Author), Martina Fendler (Author), Iliana Johannes (Author), Thomas W von Geldern (Author), Kennan Marsh (Author), Joseph D Turner (Author), Mark J Taylor (Author), Stephen A Ward (Author), Kenneth Pfarr (Author), Dale J Kempf (Author), Achim Hoerauf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4-6 weeks of doxycycline treatment can lead to permanent sterilization and adult filarial death. We investigated the anti-Wolbachia drug candidate ABBV-4083 in the Litomosoides sigmodontis rodent model to determine Wolbachia dep...