Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells

• Main Authors: Satoshi Imanishi (Author), Tomohiro Umezu (Author), Chiaki Kobayashi (Author), Tomohiko Ohta (Author), Kazuma Ohyashiki (Author), Junko H. Ohyashiki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacologica...