Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells

• Главные авторы: Satoshi Imanishi (Автор), Tomohiro Umezu (Автор), Chiaki Kobayashi (Автор), Tomohiko Ohta (Автор), Kazuma Ohyashiki (Автор), Junko H. Ohyashiki (Автор)
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• Опубликовано: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Предметы: article
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Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacologica...