Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin

• Main Authors: Ali Mahzari (Author), Songpei Li (Author), Xiu Zhou (Author), Dongli Li (Author), Sherouk Fouda (Author), Majid Alhomrani (Author), Wala Alzahrani (Author), Stephen R. Robinson (Author), Ji-Ming Ye (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study investigated the effects of matrine on non-alcoholic steatohepatitis (NASH) in mice induced by a methionine choline-deficient (MCD) diet and the mechanism involved. The study was performed in C57B/6J mice fed a MCD diet for 6 weeks to induce NASH with or without the treatment of ma...