A Novel BD2-Selective Inhibitor of BRDs Mitigates ROS Production and OA Pathogenesis

• Main Authors: Hyemi Lee (Author), Jihye Choe (Author), Min-Hee Son (Author), In-Hyun Lee (Author), Min Ju Lim (Author), Jimin Jeon (Author), Siyoung Yang (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bromodomain and extra-terminal domain (BET) family proteins regulate transcription and recognize lysine residues in histones. Selective BET inhibitors targeting one domain have attracted attention because they maintain normal physiological activities, whereas pan (nonselective) BET inhibitors do not...