In vitro and in vivo trypanocidal activity of H2bdtc-loaded solid lipid nanoparticles.

• Main Authors: Zumira A Carneiro (Author), Pedro I da S Maia (Author), Renata Sesti-Costa (Author), Carla D Lopes (Author), Tatiana A Pereira (Author), Cristiane M Milanezi (Author), Marcelo A Pereira da Silva (Author), Renata F V Lopez (Author), João S Silva (Author), Victor M Deflon (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The parasite Trypanosoma cruzi causes Chagas disease, which remains a serious public health concern and continues to victimize thousands of people, primarily in the poorest regions of Latin America. In the search for new therapeutic drugs against T. cruzi, here we have evaluated both the in vitro an...