Uterine mesenchymal tumors harboring ALK fusions and response to ALK-targeted therapy

• Main Authors: Chrisann Kyi (Author), Claire F. Friedman (Author), Jennifer J. Mueller (Author), Ryma Benayed (Author), Marc Ladanyi (Author), Maria Arcila (Author), Soo Ryum Yang (Author), Martee L. Hensley (Author), Sarah Chiang (Author)
• Format: Book
• Published: Elsevier, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory myofibroblastic tumor (IMT) of the uterus is a rare but aggressive malignancy that is often misdiagnosed. Approximately 50% of uterine IMTs (UMT) harbor rearrangements involving the ALK gene on chromosome 2p23 with subsequent overexpression of the ALK protein. Molecular characterization...