Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms

• Main Authors: Iolanda Lazaro (Author), Laura Lopez-Sanz (Author), Susana Bernal (Author), Ainhoa Oguiza (Author), Carlota Recio (Author), Ana Melgar (Author), Luna Jimenez-Castilla (Author), Jesus Egido (Author), Julio Madrigal-Matute (Author), Carmen Gomez-Guerrero (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interactive relationships between metabolism, inflammation, oxidative stress, and autophagy in the vascular system play a key role in the pathogenesis of diabetic cardiovascular disease. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a stress-sensitive guarantor of cellular homeostasis, which...