Nucleic Acid Polymers with Accelerated Plasma and Tissue Clearance for Chronic Hepatitis B Therapy

REP 2139 is a nucleic acid polymer (NAP) currently under clinical development for chronic hepatitis B (HBV) therapy. This preclinical study investigated different REP 2139 analogs that would display reduced accumulation in the serum and tissues, while retaining an antiviral effect against HBV infect...

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Príomhchruthaitheoirí: Ingo Roehl (Údar), Stephan Seiffert (Údar), Celia Brikh (Údar), Jonathan Quinet (Údar), Catherine Jamard (Údar), Nadine Dorfler (Údar), Jennifer A. Lockridge (Údar), Lucyna Cova (Údar), Andrew Vaillant (Údar)
Formáid: LEABHAR
Foilsithe / Cruthaithe: Elsevier, 2017-09-01T00:00:00Z.
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