Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

• Main Authors: Aneta M. Dobosz (Author), Justyna Janikiewicz (Author), Ewelina Krogulec (Author), Anna Dziewulska (Author), Anna Ajduk (Author), Marcin Szpila (Author), Hanna Nieznańska (Author), Andrzej A. Szczepankiewicz (Author), Dorota Wypych (Author), Agnieszka Dobrzyn (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormalities that characterize the pathophysiology of type 2 diabetes (T2D) include deficiencies of β-cells and the expansion of α-cells in pancreatic islets, manifested by lower insulin release and glucagon oversecretion. The molecular mechanisms that determine intra-islet interactions between pan...