Compound 7 regulates microglia polarization and attenuates radiation-induced myelopathy via the Nrf2 signaling pathway in vivo and in vitro studies

• Main Authors: Han Wu (Author), Jianping Wu (Author), Jianzhuo Jiang (Author), Zeyu Qian (Author), Shuang Yang (Author), Yanze Sun (Author), Hongxia Cui (Author), Shengwen Li (Author), Peng Zhang (Author), Zhiqiang Zhou (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Radiation-induced myelopathy (RM) is a significant complication of radiotherapy with its mechanisms still not fully understood and lacking effective treatments. Compound 7 (C7) is a newly identified, potent, and selective inhibitor of the Keap1-Nrf2 interaction. This study aimed...