Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity

• Main Authors: Christie M. Penniman (Author), Pablo A. Suarez Beltran (Author), Gourav Bhardwaj (Author), Taylor L. Junck (Author), Jayashree Jena (Author), Kennedy Poro (Author), Michael F. Hirshman (Author), Laurie J. Goodyear (Author), Brian T. O'Neill (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Gender influences obesity-related complications, including diabetes. Females are more protected from insulin resistance after diet-induced obesity, which may be related to fat accumulation and muscle insulin sensitivity. FoxOs regulate muscle atrophy and are targets of insulin action, but...