MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression

• Main Authors: Aijun Jia (Author), Yueling Wang (Author), Wenjin Sun (Author), Bing Xiao (Author), Yan Wei (Author), Lulu Qiu (Author), Lin Mu (Author), Li Xu (Author), Jianmin Li (Author), Xiufeng Zhang (Author), Da Liu (Author), Cong Peng (Author), Dongshan Zhang (Author), Xudong Xiang (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Th17 cells and IL-17 participate in airway neutrophil infiltration characteristics in the pathogenesis of severe asthma. Methyl-CpG binding domain protein 2 (MBD2) expression increased in CD4+ T cells in peripheral blood samples of asthma patients. However, little is known about that epigenetic regu...