Safety, tolerability, and pharmacokinetics of TG-1000, a new molecular entity against influenza virus: first-in-human study

• 主要な著者: Su-Mei Xu (著者), Li-Wen Chang (著者), Cheng-Yuan Tsai (著者), Wan-Li Liu (著者), Dai Li (著者), Shan-Shan Li (著者), Xiao-Min Li (著者), Ping-Sheng Xu (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background: The cap-snatching mechanism of influenza virus mRNA transcription is strongly suppressed by TG-1000, a prodrug rapidly metabolized into TG-0527, is a potent cap-dependent nucleic acid endonuclease inhibitor. Herein, we aimed to assess the safety, tolerability, and pharmacokinetics of TG-...