Safety, tolerability, and pharmacokinetics of TG-1000, a new molecular entity against influenza virus: first-in-human study

• Main Authors: Su-Mei Xu (Author), Li-Wen Chang (Author), Cheng-Yuan Tsai (Author), Wan-Li Liu (Author), Dai Li (Author), Shan-Shan Li (Author), Xiao-Min Li (Author), Ping-Sheng Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The cap-snatching mechanism of influenza virus mRNA transcription is strongly suppressed by TG-1000, a prodrug rapidly metabolized into TG-0527, is a potent cap-dependent nucleic acid endonuclease inhibitor. Herein, we aimed to assess the safety, tolerability, and pharmacokinetics of TG-...