Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice

• Main Authors: Ryusuke Hosoda (Author), Ryuta Nakashima (Author), Masaki Yano (Author), Naotoshi Iwahara (Author), Seidai Asakura (Author), Iyori Nojima (Author), Yukika Saga (Author), Risa Kunimoto (Author), Yoshiyuki Horio (Author), Atsushi Kuno (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging is associated with impairment of multiple organs, including skeletal muscle and heart. In this study, we investigated whether resveratrol, an activator of an NAD+-dependent protein deacetylase Sirtuin-1 (SIRT1), attenuates age-related sarcopenia and cardiomyocyte hypertrophy in mice. Treatment...