Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis

• Main Authors: Sami Gharbia (Author), Cornel Balta (Author), Hildegard Herman (Author), Marcel Rosu (Author), Judit Váradi (Author), Ildikó Bácskay (Author), Miklós Vecsernyés (Author), Szilvia Gyöngyösi (Author), Ferenc Fenyvesi (Author), Sorina N. Voicu (Author), Miruna S. Stan (Author), Roxana E. Cristian (Author), Anca Dinischiotu (Author), Anca Hermenean (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Silymarin (Sy) shows limited water solubility and poor oral bioavailability. Water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) β-cyclodextrins were designed to enhance anti-fibrotic efficiency of silymarin in CCl4-induced liver fibrosis in mice. Experimental fibrosis was induced by...