Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads.

• Main Authors: Richard O Oduor (Author), Kayode K Ojo (Author), Gareth P Williams (Author), Francois Bertelli (Author), James Mills (Author), Louis Maes (Author), David C Pryde (Author), Tanya Parkinson (Author), Wesley C Van Voorhis (Author), Tod P Holler (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), expresses two proteins with homology to human glycogen synthase kinase 3β (HsGSK-3) designated TbruGSK-3 short and TbruGSK-3 long. TbruGSK-3 short has previously been validated as a potential drug target and since this e...