An insight on the role of genetic testing of RUNX1: A key transcriptional gene in familial platelet disorder with predisposition to acute myeloid leukemia

• Үндсэн зохиолчид: Intezar Mehdi (Зохиогч), K. Ramya (Зохиогч), T.L. Suma (Зохиогч), Ashraf Mannan (Зохиогч), M.L. Sheela (Зохиогч), Shanmukh Kattragada (Зохиогч), B.S. Ajaikumar (Зохиогч), Mithua Ghosh (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2023-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Background: Familial platelet disorder (FPD) with predisposition to acute myeloid leukemia (AML) is an autosomal dominant disease of the hematopoietic system that is caused by heterozygous mutations in RUNX1 gene. RUNX1 is frequently involved in the pathogenesis of sporadic leukemia and myelodysplas...