Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

• Main Authors: Lin Zheng (Author), Chengyun Pan (Author), Dan Ma (Author), Qin Shang (Author), Tianzhen Hu (Author), Tianzhuo Zhang (Author), Qian Kang (Author), Xiuying Hu (Author), Shuyun Cao (Author), Li Wang (Author), Hong Luo (Author), Jishi Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundTumor microenvironment (TME) represents the key factor inducing leukemia development. As stromal cells within the leukemia microenvironment, Bone Marrow Mesenchymal Stem Cells (BM-MSCs) can trigger leukemia progression under certain conditions. As a critical transcription factor, nuclear f...