Sildenafil and bosentan plasma concentrations in a human immunodeficiency virus-infected patient with pulmonary arterial hypertension treated with ritonavir-boosted protease inhibitor

• Main Authors: Pierangelo Chinello (Author), Stefania Cicalini (Author), Simona Pichini (Author), Roberta Pacifici (Author), Massimo Tempestilli (Author), Maria P. Cicini (Author), Leopoldo P. Pucillo (Author), Nicola Petrosillo (Author)
• Format: Book
• Published: MDPI AG, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sildenafil and bosentan are increasingly used for the treatment of pulmonary arterial hypertension (PAH) in HIV-infected patients. However, concerns exist about pharmacokinetic interactions among sildenafil, bosentan and antiretroviral drugs, including protease inhibitors (PI). We describe here the...