Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose

• Main Authors: Danny Laurent (Author), Fiona Semple (Author), Philip J. Starkey Lewis (Author), Elaine Rose (Author), Holly A. Black (Author), Jennifer Coe (Author), Stuart J. Forbes (Author), Mark J. Arends (Author), James W. Dear (Author), Timothy J. Aitman (Author)
• Format: Book
• Published: BMC, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect and relative measurement methods, such as tissue-specific methylation and nucleosomal profiling. Method...