Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics

• Главные авторы: Jürgen B. Bulitta (Автор), Yuanyuan Jiao (Автор), Cornelia B. Landersdorfer (Автор), Dhruvitkumar S. Sutaria (Автор), Xun Tao (Автор), Eunjeong Shin (Автор), Rainer Höhl (Автор), Ulrike Holzgrabe (Автор), Ulrich Stephan (Автор), Fritz Sörgel (Автор)
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• Опубликовано: MDPI AG, 2019-07-01T00:00:00Z.
• Предметы: article
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Quinolone antibiotics present an attractive oral treatment option in patients with cystic fibrosis (CF). Prior studies have reported comparable clearances and volumes of distribution in patients with CF and healthy volunteers for primarily renally cleared quinolones. We aimed to provide the first ph...