Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics

• Main Authors: Jürgen B. Bulitta (Author), Yuanyuan Jiao (Author), Cornelia B. Landersdorfer (Author), Dhruvitkumar S. Sutaria (Author), Xun Tao (Author), Eunjeong Shin (Author), Rainer Höhl (Author), Ulrike Holzgrabe (Author), Ulrich Stephan (Author), Fritz Sörgel (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Quinolone antibiotics present an attractive oral treatment option in patients with cystic fibrosis (CF). Prior studies have reported comparable clearances and volumes of distribution in patients with CF and healthy volunteers for primarily renally cleared quinolones. We aimed to provide the first ph...