Rate-of-Kill (RoK) assays to triage large compound sets for Chagas disease drug discovery: Application to GSK Chagas Box.

• Main Authors: Juan Cantizani (Author), Pablo Gamallo (Author), Ignacio Cotillo (Author), Raquel Alvarez-Velilla (Author), Julio Martin (Author)
• 格式: 圖書
• 出版: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Chagas disease (CD) is a human disease caused by Trypanosoma cruzi. Whilst endemic in Latin America, the disease is spread around the world due to migration flows, being estimated that 8 million people are infected worldwide and over 10,000 people die yearly of complications linked to CD. Current ch...