Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability

• Main Authors: Lei Wang (Author), Mary C. Casey (Author), Sanjeev Kumar V. Vernekar (Author), Rajkumar Lalji Sahani (Author), Karen A. Kirby (Author), Haijuan Du (Author), Huanchun Zhang (Author), Philip R. Tedbury (Author), Jiashu Xie (Author), Stefan G. Sarafianos (Author), Zhengqiang Wang (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication. However, the prohibitively low metabolic stabi...