A bimolecular modification strategy for developing long-lasting bone anabolic aptamer

• Main Authors: Huarui Zhang (Author), Sifan Yu (Author), Shuaijian Ni (Author), Amu Gubu (Author), Yuan Ma (Author), Yihao Zhang (Author), Haitian Li (Author), Yuzhe Wang (Author), Luyao Wang (Author), Zongkang Zhang (Author), Yuanyuan Yu (Author), Aiping Lyu (Author), Baoting Zhang (Author), Ge Zhang (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The molecular weight of nucleic acid aptamers (20 kDa) is lower than the cutoff threshold of the renal filtration (30-50 kDa), resulting in a very short half-life, which dramatically limits their druggability. To address this, we utilized 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(4-hydroxy-2-oxo-2...