Periprostatic adipose tissue (PPAT) supernatant from obese mice releases anticontractile substances and increases human prostate epithelial cell proliferation: the role of nitric oxide and adenosine

• Main Authors: Gabriela Reolon Passos (Author), Mariana G. de Oliveira (Author), Ana Carolina Ghezzi (Author), Glaucia C. Mello (Author), Carlos Arturo Levi D'Ancona (Author), Simone Aparecida Teixeira (Author), Marcelo Nicolas Muscará (Author), Carla Beatriz Grespan Bottoli (Author), Lucilia Vilela de Melo (Author), Eliezer de Oliveira (Author), Edson Antunes (Author), Fabiola Zakia Mónica (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The prostate gland is surrounded by periprostatic adipose tissue (PPAT) that can release mediators that interfere in prostate function. In this study, we examined the effect of periprostatic adipose tissue supernatant obtained from obese mice on prostate reactivity in vitro and on the vi...