A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A

• Main Authors: Promsuk Jutabha (Author), Naohiko Anzai (Author), Keitaro Hayashi (Author), Mariko Domae (Author), Kohsuke Uchida (Author), Hitoshi Endou (Author), Hiroyuki Sakurai (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system. hNPT4 mediated time- and concentration-dependent uptake of OTxA (Km: 802.8 μM) in a pH- and voltage...