Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D

• Main Authors: Ting Shang (Author), Zhi-Sen Zhang (Author), Xin-Tong Wang (Author), Jing Chang (Author), Meng-En Zhou (Author), Ming Lyu (Author), Shuang He (Author), Jian Yang (Author), Yan-Xu Chang (Author), Yuefei Wang (Author), Ming-Chun Li (Author), Xiumei Gao (Author), Yan Zhu (Author), Yuxin Feng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mortality of sepsis and septic shock remains high worldwide. Neutrophil extracellular traps (NETs) release is a major cause of organ failure and mortality in sepsis. Targeting Gasdermin D (GSDMD) can restrain NETs formation, which is promising for sepsis management. However, no medicine is ident...