Mitochondrial Oxidative Stress and Mitophagy Activation Contribute to TNF-Dependent Impairment of Myogenesis

• Main Authors: Daniil A. Chernyavskij (Author), Olga Yu. Pletjushkina (Author), Anastasia V. Kashtanova (Author), Ivan I. Galkin (Author), Anna Karpukhina (Author), Boris V. Chernyak (Author), Yegor S. Vassetzky (Author), Ekaterina N. Popova (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many muscular pathologies are associated with oxidative stress and elevated levels of the tumor necrosis factor (TNF) that cause muscle protein catabolism and impair myogenesis. Myogenesis defects caused by TNF are mediated in part by reactive oxygen species (ROS), including those produced by mitoch...