Insights on the Multifaceted Roles of Wild-Type and Mutated Superoxide Dismutase 1 in Amyotrophic Lateral Sclerosis Pathogenesis

• Main Authors: Valentina Rubino (Author), Giuliana La Rosa (Author), Luca Pipicelli (Author), Flavia Carriero (Author), Simona Damiano (Author), Mariarosaria Santillo (Author), Giuseppe Terrazzano (Author), Giuseppina Ruggiero (Author), Paolo Mondola (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neurodegenerative disease. Cell damage in ALS is the result of many different, largely unknown, pathogenetic mechanisms. Astrocytes and microglial cells play a critical role also for their ability to enhance a deranged inflammatory response....