Insights on the Multifaceted Roles of Wild-Type and Mutated Superoxide Dismutase 1 in Amyotrophic Lateral Sclerosis Pathogenesis

• Autores principales: Valentina Rubino (Autor), Giuliana La Rosa (Autor), Luca Pipicelli (Autor), Flavia Carriero (Autor), Simona Damiano (Autor), Mariarosaria Santillo (Autor), Giuseppe Terrazzano (Autor), Giuseppina Ruggiero (Autor), Paolo Mondola (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neurodegenerative disease. Cell damage in ALS is the result of many different, largely unknown, pathogenetic mechanisms. Astrocytes and microglial cells play a critical role also for their ability to enhance a deranged inflammatory response....