Human ABC and SLC Transporters: The Culprit Responsible for Unspecific PSMA-617 Uptake?

• Autori principali: Harun Taş (Autore), Gábor Bakos (Autore), Ulrike Bauder-Wüst (Autore), Martin Schäfer (Autore), Yvonne Remde (Autore), Mareike Roscher (Autore), Martina Benešová-Schäfer (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2024-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

[¹⁷⁷Lu]Lu-PSMA-617 has recently been successfully approved by the FDA, the MHRA, Health Canada and the EMA as Pluvicto^®. However, salivary gland (SG) and kidney toxicities account for its main dose-limiting side-effects, while its corresponding uptake an...