Human ABC and SLC Transporters: The Culprit Responsible for Unspecific PSMA-617 Uptake?

• Main Authors: Harun Taş (Author), Gábor Bakos (Author), Ulrike Bauder-Wüst (Author), Martin Schäfer (Author), Yvonne Remde (Author), Mareike Roscher (Author), Martina Benešová-Schäfer (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

[¹⁷⁷Lu]Lu-PSMA-617 has recently been successfully approved by the FDA, the MHRA, Health Canada and the EMA as Pluvicto^®. However, salivary gland (SG) and kidney toxicities account for its main dose-limiting side-effects, while its corresponding uptake an...