An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis

• Main Authors: Douglas Steinhauff (Author), Mark Martin Jensen (Author), Ethan Griswold (Author), Jolanta Jedrzkiewicz (Author), Joseph Cappello (Author), Siam Oottamasathien (Author), Hamidreza Ghandehari (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2022-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Semisynthetic glycosaminoglycan ethers (SAGEs) are short, sulfated hyaluronans which combine the natural properties of hyaluronan with chemical sulfation. In a murine model, SAGEs provide protection against radiation induced proctitis (RIP), a side effect of lower abdominal radiotherapy for cancer....