An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis

• Egile Nagusiak: Douglas Steinhauff (Egilea), Mark Martin Jensen (Egilea), Ethan Griswold (Egilea), Jolanta Jedrzkiewicz (Egilea), Joseph Cappello (Egilea), Siam Oottamasathien (Egilea), Hamidreza Ghandehari (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Semisynthetic glycosaminoglycan ethers (SAGEs) are short, sulfated hyaluronans which combine the natural properties of hyaluronan with chemical sulfation. In a murine model, SAGEs provide protection against radiation induced proctitis (RIP), a side effect of lower abdominal radiotherapy for cancer....