L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo

• Główni autorzy: Mingfei Zhu (Autor), Hong Wang (Autor), Chenglin Wang (Autor), Yanfen Fang (Autor), Tong Zhu (Autor), Weili Zhao (Autor), Xiaochun Dong (Autor), Xiongwen Zhang (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more inhibitors are in clinical investigation. However...