The impact of valproic acid and 2-propyl-4-pentenoic acid on antioxidant status measured by GSH/GSSG ratio and FRAP levels in acute and chronic exposure

• Main Authors: Karina Sommerfeld-Klatta (Author), Magdalena Łukasik-Głębocka (Author), Sylwia Kobyłka (Author), Barbara Zielińska-Psuja (Author)
• Formato: Livro
• Publicado em: Polskie Towarzystwo Farmaceutyczne, 2023-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Valproic acid (VPA) is a broad-spectrum anticonvulsant drug. Its mechanism of action includes enhancing GABAergic transmission, blocking voltage-gated sodium channels, and affecting dopaminergic and serotonergic transmission (1). The mechanism of VPA toxicity, including its effects on the liver, is...